Featured Research Areas
We are studying how osteoarthritis (OA) occurs with different risk factors, such as aging and obesity, with particular interests in studying the role of cellular metabolism in OA pathogenesis.
Our recent findings demonstrate that one type of protein post-translational modification-lysine malonylation (MaK) is involved in chondrocyte metabolic dysfunctions during aging and obesity. We are studying how MaK is dysregulated and testing if MaK is good therapeutic target for OA. Another line of research is focused on studying the role of growth hormone (GH) in chondrocyte metabolism and OA development during aging.